ACTH is extracted from the pituitary glands of animals or made synthetically. ACTH stimulates the adrenal glands to release glucocorticoid hormones. These hormones are anti-inflammatory in nature, reducing edema and other aspects of inflammation. Data from the early 1970s indicate that ACTH may reduce the duration of MS exacerbations. In recent years it has been determined that synthetically produced glucocorticoid hormones (e.g., cortisone, prednisone, prednisolone, methylprednisolone, betamethasone, dexamethasone), which can be directly administered without the use of ACTH, are more potent, cause less sodium retention and less potassium loss, and are longer-acting than ACTH.

This definition is in context to Multiple Sclerosis. See more contextual defintions for Acth (Adrenocorticotropic Hormone).